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Norverapamil hydrochloride

CAS No. 67812-42-4

Norverapamil hydrochloride( ±)-Norverapamil hydrochloride | D591 hydrochloride )

Catalog No. M15590 CAS No. 67812-42-4

A calcium channel blocker and the main active metabolite of verapamil.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Norverapamil hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A calcium channel blocker and the main active metabolite of verapamil.
  • Description
    A calcium channel blocker and the main active metabolite of verapamil.
  • In Vitro
    Norverapamil hydrochloride ((±)-Norverapamil hydrochloride) is similarly effective as verapamil at inhibiting isoniazid and rifampicin tolerance and killing of intracellular M. tuberculosis in the absence of other drugs. norverapamil, also inhibits macrophage-induced tolerance and achieves similar serum levels to verapamil. Verapamil and its major metabolite norverapamil were identified to be both mechanism-based inhibitors and substrates of CYP3A and reported to have non-linear pharmacokinetics in clinic.
  • In Vivo
    Norverapamil hydrochloride (9 mg/kg; p.o.), a major metabolite of verapamil, has terminal half-life, AUC and Cmax values of 9.4 hours, 260 ng?h/ml, and 41.6 ng/mL, respectively. Animal Model:Male Sprague-Dawley rats Dosage:9 mg/kg (Pharmacokinetic Study)Administration:Oral administration Result:t1/2=9.4 hours;AUC=260 ng?h/mL;Cmax=41.6 ng/mL.
  • Synonyms
    ±)-Norverapamil hydrochloride | D591 hydrochloride
  • Pathway
    GPCR/G Protein
  • Target
    Calcium Channel
  • Recptor
    Calcium Channel
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    67812-42-4
  • Formula Weight
    477.036
  • Molecular Formula
    C26H37ClN2O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 31 mg/mL
  • SMILES
    N#CC(C(C)C)(C1=CC=C(OC)C(OC)=C1)CCCNCCC2=CC=C(OC)C(OC)=C2.[H]Cl
  • Chemical Name
    Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, hydrochloride (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lee YS, et al. Xenobiotica. 2012 Aug;42(8):766-74. 2. Adams KN, et al. J Infect Dis. 2014 Aug 1;210(3):456-66. 3. Sawicki W. Eur J Pharm Biopharm. 2002 Jan;53(1):29-35.
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